O Papel da Epigenética na Periodontite: da Patobiologia às Novas Terapias

Publicado 2024-12-27

  • Fernanda Cristina Silva Picone
    • ,
  • Anne Carolina e Leite
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Palavras-chave: Periodontite, Epigenética, Doença Periodontal, Sistema Imunológico, Inflamação

Resumo

O estudo investigou o papel dos mecanismos epigenéticos, como a metilação do DNA, modificações nas histonas e a regulação por microRNAs, na patobiologia da periodontite. A pesquisa baseou-se em uma revisão de literatura conduzida na base de dados PubMed, abrangendo trabalhos publicados ao longo das últimas duas décadas, que analisaram conceitos clássicos e inovadores sobre como fatores ambientais e comportamentais, como tabagismo e dieta, podem alterar processos epigenéticos, impactando a resposta inflamatória e imunológica do hospedeiro e contribuindo para a progressão da doença. O referencial teórico destaca a interação entre epigenética, disbiose e destruição tecidual, ampliando a compreensão da fisiopatologia da periodontite. Os resultados indicam que mudanças epigenéticas não apenas intensificam a inflamação e a destruição tecidual, mas também abrem novas perspectivas para o desenvolvimento de estratégias terapêuticas inovadoras baseadas na epigenética para o controle e prevenção da doença. Conclui-se que uma abordagem integrativa, que considere fatores epigenéticos e ambientais, é crucial para o avanço no manejo da periodontite.

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Picone, F. C. S., & Leite, A. C. e. (2024). O Papel da Epigenética na Periodontite: da Patobiologia às Novas Terapias. Brazilian Journal of Biological Sciences, 11(25), e117. https://doi.org/10.21472/bjbs.v11n25-039

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