Nutrigenomics and Gene Modulation Associated with Cardiovascular Diseases

Resumo

Introduction: Cardiovascular diseases (CVD) are responsible for 31% of global mortality, most in the form of coronary heart disease (CHD) and stroke. Nutrigenomics and nutrigenetics have been tools in the prevention and treatment of cardiovascular diseases. Objective: to review the main polymorphisms related to food metabolism that can be used in the diagnosis and monitoring of cardiovascular diseases. Material and Methods: This study is qualitative and descriptive through a literature review that consulted the PubMed, Virtual Health Library, Scielo, Capes Portal and Google Scholar databases with original articles published in Portuguese and English in the period between January 2010 and September 2021. Results: 26 articles were found as potentially in accordance with the search criteria. After analyzing the abstracts, 17 articles (65.38%) were excluded and 10 (38.46%) articles were selected. Discussion: Benefits of changing the dietary pattern were found that can promote prevention and reduce the risk of cardiovascular events. Conclusion: The use of bioactive substances can contribute positively to modulating the expression of genes associated with increased cardiovascular risk.

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