Physicochemical study of Delphinium denudatum Wall (Ranunculales: Ranunculaceae) and their antioxidant activity

Resumo

The drug jadwar known as Delphinium denudatum Wall (Ranunculales: Ranunculaceae), the jadwar consist of dried tuberous roots of D. denudatum. An annual glabrous or slightly downy herbs found is Western Himalayas from Kumaon to Kashmir at altitudes of 3,000 m to 4,500 m specially on grassy slopes. It is distinguished by its relatively small blue and violet color and it is one of the important drugs used as indigenous medicine in India, especially in where isolated from the petroleum ether-soluble fraction of roots of D. denudatum. Jadwar widely used in traditional unani system of medicine for the treatment of a variety of human ailments including epilepsy. In order to increase the bioavailability, the nanophytosome of the D. denudatum root aqueous fraction (DNP) was prepared, characterized and evaluation. The phospholipids complex of the obtain aqueous fraction (AF) was prepared with phospholipon 90H. The size of nanophytosome was determined by dynamic light scattering. HPTLC fingerprinting of the AF was also performed.

Referências

1. Anonymous. The wealth of India. Raw
2. materials. New Delhi: CSIR: 1952. v. 3.
3. India. Unani pharmacopoeia of India. New
4. Delhi: Department of Ayush, 2009. v. 6.
5. Kamboj, A.; Saluja, A. K. Isolation of stigma
6. sterol and β-sitosterol from petroleum ether
7. extract of aerial parts of Ageratum conyzoides
8. (Asteraceae). International Journal of
9. Pharmacy and Pharmaceutical Sciences, v.
10. , p. 94-96, 2011.
11. Mohanapriya, S.; Siva, G. V. Antioxidant and
12. bioactive constituent and its compounds.
13. Journal of Nutritional Science and
14. Vitaminology, v. 2, p. 138-141, 2013.
15. Patra, A.; Jha, S.; Murthy, P. N.; Manik;
16. Sharone, A. Isolation and characterization of
17. stigmast-5-en-3β-ol (β-Sitosterol) from the
18. leaves of Hygrophila spinosa T. Anders.
19. International Journal of Pharmaceutical
20. Sciences and Research, v. 1, p. 95-100,
21. Rahman, A.; Nasreen, A.; Akhtar, F.; Shekhani,
22. M. S.; Clardy, J.; Parvez, M.; Choudhary, M. I.
23. Antifungal diterpenoid alkaloids from
24. Delphinium denudatum Wall. Journal of
25. Natural Products, v. 60, no. 5, p. 472-474,
26. Rawat, V. S.; Jalal, J. S. Sustainable utilization
27. of medicinal plants by local community of
28. Uttarkashi District of Garhwal, Himalaya,
29. India. European Journal of Medicinal
30. Plants, v. 1, no. 2, p. 18-25, 2011.
31. Wagner, H.; Bladt, S. Plant drug analysis:
32. A thin layer chromatography Atlas. 2. ed.
33. New York: Springer-Verlag, 1996.
34. Yoshida, Y.; Niki, E. Antioxidant effects of
35. phytosterols and its components. Journal of
36. Nutritional Science and Vitaminology, v.
37. , p. 277-280, 2003.